SOD1 and amyotrophic lateral sclerosis: As an attractive therapeutic strategy for diseases, such as ALS, consists of boosting the Hsp levels in neurons and glial cells [10,19], in the present work we investigate if histamine signaling exerts its neuroprotective action through the HSR triggered in vitro in motor neurons and microglia cultures, and in vivo in spinal cord and cortex from symptomatic SOD1-G93A mice.