CASR and diabetic kidney disease: Cinacalcet, a type II agonist of the calcium-sensing receptor (CaSR) that increases the expression of SOD1 and SOD2 antioxidant enzymes and decreases the levels of urinary 8-hydroxy-deoxyguanosin and isoprostane, has been shown to attenuate diabetic nephropathy in db/db mice by modulation of autophagy through the CaMKKβ-LKB1-AMPK pathway [142].