GNRH1 and polycystic ovary syndrome: Consistent with these findings, a recent study in the PNA PCOS model has shown that treatment with flutamide, an androgen receptor antagonist, can reverse abnormal GnRH neuron morphology, decrease T levels, and restore estrous cyclicity in PNA mice [93], suggesting that hyperandrogenemia is causing, directly or indirectly, some of the GnRH abnormalities (other aspects of GnRH physiology or upstream afferent circuits were not studied).