In this regard, we have to mention that AKT2 induces the proliferation and migration of RA fibroblast-like synoviocytes [63], JUND can contribute to bone erosion [64], RELA is a key component of the NF-kB transcription factor crucially involved in RA [65], and SRC has bone resorptive properties. Here, JUND is linked to rheumatoid arthritis.