PLAU and rheumatoid arthritis: Pathways involved in vascular biology were also significantly enriched in DEGs modulated by RP11-498C9.15, including “PAR1-mediated thrombin signalling events,” “urokinase-type plasminogen activator (uPA)/uPAR-mediated signalling,” and “endothelins” signalling; indeed, it is well known that RA patients have generalized vasculopathy and finger blood flow abnormalities.