In fact, CBP/p300 mediates the tumor suppressor function of p53 [71], Forkhead box protein O3 (FOXO3A) [72] and Breast cancer type 1 susceptibility protein (BRCA1) [73], while on the other hand, together with c-Myc [74], c-Myb [75] and androgen receptor (AR) co-activators [76], they can promote cancer progression. The gene discussed is CREBBP; the disease is cancer.