Albeit in a different cellular model, i.e., in non-small-cell lung cancer (NSCLC) cells A549, it is intriguing that both HMGA1 and YB-1 have been demonstrated to bind to the promoter of cyclin D1 and to be responsible for its transcriptional regulation [98,99]. The gene discussed is CCND1; the disease is non-small cell lung carcinoma.