A recent study by Kotula et al. in the cutaneous melanoma cell line SK28 demonstrated that DNA-PKcs has pro-metastatic activity by modulating the tumor microenvironment through controlling the secretion of, e.g., matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) [84]. The gene discussed is PRKDC; the disease is neoplasm.