DNAH8 and Hyperglycemia: Since it has been shown that oxidative phosphorylation rates and and ATPase-activities were markedly depressed in mitochondria from heart preparations under pathological conditions, including hyperglycemia [52], our similar findings in the present study strongly support the current hypothesis related with the important role of mitochondrial function via changes not only in [Zn2+]i but also in [Zn2+]Mit in heart dysfunction during aging with insulin resistance development.