Taken together, our data suggest that the main regulator of the NFkB pathway in uveal melanoma is loss of chromosome 3 and BAP1: loss of chromosome 3/loss of BAP1 expression correlates with upregulation of the NFkB pathway and affects the activity of the NFkB pathway in UM tumors, which leads to upregulation of HLA Class I expression and attraction of infiltrating cells to the tumor environment which is a well known factor in the development of metastasis in this disease. This evidence concerns the gene NFKB1 and uveal melanoma.