The binding of Wnt5a ligand leads to ROR1 receptor dimerization and the recruitment of various adaptor proteins that trigger the activation of downstream Rho/Rac1 GTPases [12,13,16], PI3K/AKT [17,18,19] and the Hippo-YAP/TAZ pathway [19,20,21], contributing to several biological processes which ultimately lead to tumor progression and chemoresistance. Here, WNT5A is linked to neoplasm.