RHOA and cancer: Prior studies have also shown that RhoA inhibits Lats1/2 to activate YAP/TAZ, while analysis of gene expression data from cancer cell lines revealed a direct correlation between YAP/TAZ and Wnt5a/b levels, indicating that non-canonical Wnt signaling via Wnt5a/b is able to induce YAP/TAZ activation in cancer cells [67].