ROR1 and B-cell chronic lymphocytic leukemia: In similar studies for hematological cancers, the combination of cirmtuzumab and ibrutinib was more efficient in eradicating leukemic cells in vivo [74], whereas the ex vivo co-targeting of ROR1 and Bcl-2 in CLL, MCL or B-ALL patient samples was significantly more effective than targeting a single pathway, strongly supporting the implementation of these combinatorial regimens in clinical trials [13,39,40].