Primary hemostatic disorder occurs in dogs with experimentally induced CKD, indicated by a prolongation in BMBT.11 However, the underlying mechanism is unknown as there are increased vWF:Ag concentrations, no change in multimeric distribution of vWF,11 and normal AA‐, ADP‐, and COL‐induced LTA.10 This is contrary to our findings which characterized primary hemostatic disorders in naturally occurring AKI with decreased COL‐induced platelet aggregometry, and abnormal binding of vWF to COL, as indicated by the high vWF:Ag:vWF:CBA ratio. This evidence concerns the gene RENBP and chronic kidney disease.