CASP8 and breast cancer: The gene expression analysis showed upregulation of p53, Bax, and caspases 8, 9, and 3, in the breast cancer cell line (MDA -MB-231) treated with the FHRH extract, where the fold changes were 18.08 ± 2, 2.07 ± 0.07, 13.4 ± 0.4, 3.07 ± 0.3, and 2.43 ± 0.2, respectively, compared to the untreated control group where the mean changes were 1.30 ± 1.2, 0.9 ± 0.11, 2 ± 0.7, 1.02 ± 0.3, and 1.02 ± 0.3, respectively.