While the intensity of IRF4 binding to IL-10 DNA of CD4+CD25hiFoxp3+Tregs was higher than that of CD4+CD25−Teffs cells in ITP patients (1.16 ± 0.06 vs 0.12 ± 0.03, p=0.034). This evidence concerns the gene CD4 and autoimmune thrombocytopenic purpura.