In the current study, we aimed to investigate the expressions of IL-10 and the immunosuppressive function of Treg regulated by IRF4 and the impact on the balance of Th17/Treg in newly diagnosed ITP patients, in order to better understand the pathogenesis of ITP, and could pave ways to specific immune therapy targeting ITP and other autoimmune diseases. This evidence concerns the gene IRF4 and autoimmune thrombocytopenic purpura.