SORT1 and hyperlipidemia: Studies of SORT1 and PSRC1 overexpression in mouse models of hyperlipidemia showed that, while PSCR1 overexpression had no metabolic effects, SORT1 overexpression led to a significant reduction in plasma LDL-C and very low-density lipoprotein (VLDL) particle levels by modulating hepatic VLDL secretion, suggesting an important role of SORT1 in CAD (74).