As an example, restricted expression of BCR-ABLp210 to hematopoietic stem-progenitor cells (HS/PC) leads to CML in vivo by inducing a global hypomethylation in the stem cells (the cell-of-origin) that is maintained in the mature myeloid tumor cells (Vicente-Duenas et al., 2019). This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.