IDH1 and acute myeloid leukemia: Studies have identified that the earliest mutations in AML occur most commonly in epigenetic regulators, in particular DNMT3A, TET2, and IDH1/2 followed by secondary mutations in genes associated with signal transduction pathways and cellular proliferation (Corces-Zimmerman et al., 2014; Shlush et al., 2014; Chotirat et al., 2015; Eriksson et al., 2015; Sato et al., 2016).