Furthermore, CD70/CD27 may be associated with a more aggressive CML phenotype, as CD70/CD27 was upregulated in AML blast cells and progenitors, and increased levels of soluble CD27 is used as a prognostic biomarker for poor overall AML survival (Riether et al., 2017). Here, CD27 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.