Sirtuin 1 (SIRT1) is a NAD-dependent HDAC upregulated in CD34+ CML cells compared to normal hematopoietic progenitors and has been implicated in leukemogenesis and the survival of CML LSCs through its activity on a non-histone target p53 (Li et al., 2012; Yuan et al., 2012). This evidence concerns the gene TP53 and chronic myelogenous leukemia, BCR-ABL1 positive.