IDH1 and leukemia: Vitamin C treatment has also been tested on IDH1 mutant mouse leukemia cells where it was shown to induce a Tet2-dependent gain of 5hmC, loss of 5mC and the up-regulation of gene expression signatures that correlate with decreased leukemia stem cell self-renewal and increased differentiation toward a mature myeloid phenotype (Mingay et al., 2018).