In contrast to these findings, interference of Rac1-Bcl-2 complex either by inhibition or siRNA mediated depletion of Rac1 relieved mitochondrial oxidative stress and promoted neuronal survival in a focal cerebral ischemia in vivo in a diabetic rat model and a hyperglycemia-exposed PC-12 cell in vitro model (Pan et al., 2018). This evidence concerns the gene RAC1 and Hyperglycemia.