We have published that treatment of cells with either [pazopanib + HDAC inhibitor] or [neratinib + HDAC inhibitor] increases the levels of autophagosomes and autolysosomes in tumor cells, and that knock down of the autophagy regulatory proteins Beclin1 or ATG5 significantly suppressed autophagy and tumor cell killing. The gene discussed is BECN1; the disease is neoplasm.