Wu et al. revealed that EXOSC5 was upregulated in leukemic blasts from patients with acute myelogenous leukemia and chronic myelogenous leukemia blast crisis but is barely detectable in normal bone marrow, normal peripheral blood, or leukemic cells from patients with stable-phase CML (7). The gene discussed is EXOSC5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.