Given that exaggerated profiles of the MELK/EZH2/NF-κB axis are being identified in tissues with a high percentage of Ki-67+, such as the embryonic subventricular zone (SVZ) and in high-grade gliomas (Figure 1B and Figure S4), it seems likely that these proteins function to promote proliferation. This evidence concerns the gene NFKB1 and central nervous system cancer.