PVT1 and neoplasm: PVT1 also plays a role in regulating the apoptosis of tumor cells through activating c-MET/PI3K/AKT and co-activator-associated arginine methyltransferase 1 (CARM1) signaling pathways by sponging miR-152 and miR-424-5p, respectively (5, 28) (Figure 1).