The immunoblotting analysis revealed processing of p100 into p52 in BAFFR+ pre-B-ALL cells and in the 697 cell line, but not in the BAFFR− common B-ALL sample (Figure 3A), demonstrating that BAFFR expressed in pre-B ALL is functional and initiates NF-κB2 signaling similar to mature B-cells. This evidence concerns the gene TNFRSF13C and acute lymphoblastic leukemia.