ChIPs in pre-B-ALL cells (697) that carry the E2A-PBX1 fusion and express only BAFFR, mimicking patients' phenotype, evaluated whether E2A-PBX1 binds in vivo to sequences of the BAFFR gene that include PBX consensus motifs (promoter, intronic and 3′UTR). Here, TNFRSF13C is linked to acute lymphoblastic leukemia.