Herein, E2A-PBX1 was shown to bind to BAFFR promoter, providing a potential functional implication in the regulation of BAFFR expression in pre-B-ALL E2A-PBX1+ cells, probably as part of a transcriptional complex, and a framework for further studies. Here, TNFRSF13C is linked to precursor B-cell acute lymphoblastic leukemia.