A recent study showed that brusatol induces HIF-1α degradation in colon cancer.120 Furthermore, brusatol pre-treatment under hypoxia condition down-regulates the expression of HIF-1α downstream genes, including GLUT1 and PDK1. Curcumin blocks glucose uptake in GLUT1 expressing cells up to 86%.121. This evidence concerns the gene HIF1A and colonic neoplasm.