ERBB2 and breast carcinoma: Ethyl acetate fraction of C. sappan decreases the protein level of MMP-2, MMP-9, and HER-2; thus inhibits cell migration in HER-2 overexpressed-breast cancer cells.78 Brazilein down-regulates MMP-2 and MMP-9.79,80 Whereas, brazilin decreases 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasion in MCF-7 breast cancer cells through down-regulation of MMP-9 expression.81