MMP9 and cancer: B. javanica oil inhibits metastasis by up-regulating integrin.76 Thymoquinone reduces the expression of MMP-9, hence suppresses metastasis to multiple vital organs, including lungs, brain, and bone in the animal model of cancer.66 Thymoquinone down-regulates the expression of HER-2 and reduces the motility and migration of a highly metastatic pancreatic cancer cell line.77