Thymoquinone selectively inhibits the proliferation of prostate cancer cells by suppressing AR overactivation.27 Curcumin also inhibits AR expression in prostate cancer cells.28 The aqueous extract of B. javanica attenuates EGFR activity in liver cancer and human non-small-lung cancer cells; resulting in the inhibition of cancer proliferation.29,30 Ethanolic extract of C. sappan inhibits HER2 expression in breast cancer cells.31 Interestingly, curcumin shows an impressive activity against various RTKs, including EGFR and HER-2, in colon cancer cells.32 This evidence concerns the gene ERBB2 and Familial prostate cancer.