Also, Fenretinide, which is a synthetic cytotoxic retinoid, acts by down-regulating the activity of Bcl-2 and Mcl-1 without altering the expression of pro-apoptotic protein Bax.40 Many HDACi have entered phase I to III clinical trials such as, CHR-3996 used for a Refractory solid tumor in phase I.115 Another inhibitory agent Panobinostat (LBH589) used for Relapsed or refractory NHL and advanced solid tumors and Panobinostat (LBH589) along with melphalan for Relapsed or multiple refractory myelomas in I and II phase.116-118. This evidence concerns the gene BCL2 and non-Hodgkin lymphoma.