Various approaches that have taken to reduce or suppress the anti-apoptotic function of cFLIP involve the use of siRNA (small interfering RNA), use of many small molecules and agents that down-regulate cFLIP.91 Specifically, siRNA inhibits the expression of c-FLIP and prepare cancer cells to be receptive or sensitize for TRAIL, FASL, and chemotherapeutic agents that induce apoptosis. The gene discussed is CFLAR; the disease is cancer.