Superoxide anion radical (O2−•) produced by charge transfer between the light‐excited PS and adjacent substrates in tumor cells is one of the primary and highly cytotoxic ROS generated from the type I mechanism.20, 21, 22 It reacts with proteins, DNA, or lipids, to achieve irreversible cellular components damage and dysfunction in cell metabolism and even cell apoptosis.23 Moreover, under the intracellular superoxide dismutase (SOD)‐mediated disproportionation reactions, O2−• molecule further converts to hydrogen peroxide (H2O2) and O2. This evidence concerns the gene SOD1 and neoplasm.