While PLG‐CA4 induced a significantly high level of hypoxia‐inducible factors 1‐α (HIF1‐α) translocated in the nucleus (Figure 1e), which was stabilized only under hypoxic conditions.9 The hypoxic tumor microenvironment is known to subvert the function of macrophages through direct or indirect regulation by tumor cells,16 and thus, we examined the number of tumor‐infiltrating macrophages as well as the phenotype modulation. This evidence concerns the gene CA4 and neoplasm.