CA4 and neoplasm: Compared to the monotherapy of PLG‐CA4, the combination of PLG‐CA4 and PI3Kγ inhibitor markedly suppressed the recruitment of circulating macrophages to tumors, thereby significantly lowering the level of immunosuppressive TAM‐M2 (2.0 × 104 to 1.5 × 104 per tumor) (Figure5a).