CA4 and neoplasm: Several studies demonstrated that PI3Kγ blockade in macrophages stimulates the pro‐inflammatory responses to promote the adaptive immunity.17 Compared to the monotherapy, the number of infiltrating CD8+ T lymphocytes was markedly increased in mice treated with PLG‐CA4 plus PI3Kγ inhibitor (3.0 × 104 to 5.7 × 104 per tumor), suggesting that less immunosuppressive phenotype of the macrophages was tightly associated with CTLs trafficking into the tumors (Figures 5b,c).