Interestingly, a previous study has implicated that macrophage‐dominant PI3Kγ controls the stability of hypoxia‐induced HIF1‐α and HIF2‐α, and directs the tumor proliferation, angiogenesis, and metastasis.37 Genetic or pharmacological inhibition of p110γ in mice models significantly decreases the number of HIFα and its related downstream transcription targets in response to hypoxia. This evidence concerns the gene EPAS1 and neoplasm.