CA4 and neoplasm: Tumor aggression and metastasis were increasingly characterized as the dynamic correlation between the tumor cells and tumor microenvironment, while matrix metalloproteinases (MMPs) serve as potential biomarkers of tumor progression and metastatic spread in this process, for example, MMP9.23 Furthermore, the expression of MMP9 protein and gene was significantly decreased in tumor tissues treated with PLG‐CA4 and PI3Kγ inhibitor combination (Figure 5f).