In earlier studies, monensin induced apoptosis-associated changes in Bax, caspase-3, and caspase-8 (Park et al., 2002), elevated intracellular oxidative stress (Ketola et al., 2010) in several human cancer cells, or exerted effects on the intracellular trafficking and processing of endocytosis (Nishimura et al., 2015). This evidence concerns the gene CASP3 and cancer.