ID3 and pulmonary arterial hypertension: Gene expression and machine learning analysis exhibited ID3 as candidate target genes in PAH and HHT tissue and blood samples. ID3 and candidate target genes including ABCB6, ACP1, BYSL, CAD, CDH15, DCBLD2, DHRS3, DNMT1, ID3, MCM4, and NDUFA7 were shown to be essential to various vascular remodeling pathways such as focal adhesion, oxidative phosphorylation, and cell cycle [66].