CYP46A1 and diabetes mellitus: However, the effect of hydroalcoholic extract of ginger on the alteration of some enzymes involved in brain cholesterol homeostasis, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HM G-CoA reductase) and cytochrome P450 family 46 subfamily A member 1 (CYP46A1), is poorly understood in diabetes.