TP53 and ovarian cancer: The analysis of transcriptional levels of two apoptotic-related genes, p53 and Bcl-2 in human ovarian cancer cells incubated with IC50 concentrations of brittle star polysaccharide, paclitaxel and co treatment showed that the pretreatment of A2780cp cells with polysaccharide, taxol and synergistic treatment down regulated Bcl-2 expression and up regulated p53 mRNA level (Figure 7).