The increased expression of apoptosis-related proteins cleaved Casp3 and Casp8 was found in the retina of the ischemia-injured rats (1.81 and 1.63 folds, respectively, p < 0.05) when compared to that of the uninjured normal rats (Figures 4(b) and 4(c)). Here, CASP8 is linked to ischemia.