Moreover, knowing that cell sensitivity to H2O2 largely depends on cell type and that AQPs are aberrantly expressed in many tumors, particularly in the most aggressive, the effect of H2O2 on the AQP1, AQP3, and AQP5 expression profile was investigated in breast cancer cell lines representing different breast cancer malignancies, together with their response to oxidative stress and reaction to the Nrf2 transcription factor. The gene discussed is AQP5; the disease is breast cancer.