In summary, SMP-3 extract had powerful anti-inflammation activity in vitro, by suppressing of NO production, p65 nuclear translocation, and NLRP3 expression. In vivo, SMP-3 was able to prevent the paw edema, reduce gouty joint inflammatory features, and decrease the release of IL-1β, PGE-2, IL-8, and NO levels in gouty arthritis rats. Here, NLRP3 is linked to gout.