BECN1 and Alzheimer disease: Interestingly, administration of TSG in APP695V717I transgene mice (transgene animal model of Alzheimer's disease, AD) can suppress the expression of Beclin 1 and LC3-II in hippocampal tissues of mice, which can thereby improve the learning, memory, and spatial orientation behavior of the APP695V717I transgene mice, suggesting that TSG can inhibit autophagy to exert the role of anti-AD [9].