Metabolic stress modulates β-secretase gene transcription and β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) protein levels in AD through the sirtuin 1 (SIRT1)-PPARγ-proliferator-activated receptor γ coactivator 1 (PGC-1) pathway [146]. Here, SIRT1 is linked to Alzheimer disease.