In particular, Kim and colleagues revealed that treatment of MCF-7, MDA-MB-231, and SUM159 human breast cancer cells with Benzyl isothiocyanate (BITC), a constituent of cruciferous vegetables, increases levels of the active form of Notch1, Notch2, and Notch4 in both cultured and xenografted cells. Here, NOTCH4 is linked to breast carcinoma.