ESR1 and breast cancer: In a meta-analysis of 4,754 ER- breast cancer cases and 31,663 controls from three GWAS, SNP rs2284378 on chromosome 20q11 was associated with ER- tumors (P=1.1x10−8) and showed a stronger association with TNBC (OR=1.16, P=6.4x10−3) than for ER-/HER2+ tumors (OR=1.07; P=0.41), although the differences did not reach statistical significance [60].