The BRCA2 binding protein known as partner and localizer of BRCA2 (PALB2) stabilizes and regulates BRCA2 through localization and stabilization within important nuclear structures such as chromatin and the nuclear matrix and by promotion of recombination repair and checkpoint functions [36]. PALB2 was recently classified as a high-risk breast cancer gene with an odds ratio (OR) of 7.46 [95% confidence interval (CI)=5.12-11.19] [37]. The gene discussed is PALB2; the disease is breast carcinoma.