The AUC area of the CPR (0.728, 95% CI: 0.678-0.774) was higher than that of CAR (0.702, 95% CI: 0.651-0.750), CRP (0.702, 95% CI: 0.651-0.750), ALB (0.573, 95% CI: 0.519-0.625), and PALB (0.686, 95% CI: 0.635-0.735) for all the ESCC patients (Figure 5). The gene discussed is TTR; the disease is esophageal squamous cell carcinoma.