CELF2 is a tumor suppressor (Subramaniam et al., 2011; Ramalingam et al., 2012), and EFR3B contributes to the control of the phosphorylation state and could affect the responsiveness of G-protein-coupled receptors in higher eukaryotes (Bojjireddy et al., 2015). Here, EFR3B is linked to neoplasm.