These immune response genes were involved in both the acquired and innate immune responses, for example, IRF8 (Rustaqi; BTA18) and ABCC2 (Rustaqi; BTA26) linked to the acquired immune response to protozoan and bacterial infections (Giagu, 2016) and gastrointestinal nematodes (Li et al., 2011), respectively; PARM1, an innate immune response gene (Jenoubi breed; BTA6), associated with anti-apoptotic activity especially during fertility stage (Cochran et al., 2013); and ATG7 (innate response gene, Jenoubi; BTA22), linked to the autophagy process (Aboelenain et al., 2015). This evidence concerns the gene ABCC2 and bacterial infectious disease.