Using luciferase reporter hepatitis C virus (Jc1-HCVcc) infection model and the induction of MxA and IFIT1 as readouts, we determined the treatment conditions for subsequent functional experiments as follows: 1 ng/mL for IFNα2b and 25 ng/mL for IFNλ1 and both for 8–24 h (Supplementary Figures 1A–F). Here, MX1 is linked to infection.