While, osteoporosis, mediated by both transrepression (osteocalcin transcription) and transactivation (osteoblast differentiation) and thus requiring both GR monomers and dimers (95), was not induced by CpdA, either in vitro or in vivo (105–109), while the GRdim mice still developed osteoporosis concomitant with a potent suppression of osteoblast differentiation both in vitro and in vivo (110–112). The gene discussed is NR3C1; the disease is osteoporosis.