IL6 and Thrombocytopenia: For intraperitoneal application doses commonly range between 1 and 10 mg/kg which induces prolonged thrombocytopenia, platelet sequestration and innate immune cell infiltration into lungs and liver, changes in the coagulation state and an inflammatory cytokine response involving TNF-α and IL-6, which may eventually lead to death (23, 134).