We recently reported the downregulation of 3 genes that can predict BOS at least 6 months before diagnosis using microarray-based gene expression profiling: POU class 2 associating factor 1 (POU2AF1), T cell leukemia/lymphoma protein 1A (TCL1A) and B cell lymphocyte kinase (BLK)(75). The gene discussed is POU2AF1; the disease is Buschke-Ollendorff syndrome.