CD4 and Buschke-Ollendorff syndrome: Interestingly, Mamessier et al. also found increases in CD3+CD4+CD25highCD69− Tregs numbers in both peripheral blood and BALF compared to those in stable LTRs, but they also observed increased levels of Tregs in BALF from BOS patients whose functional decline stopped compared to those in BALF from patients with evolving BOS (54).