TNF and Buschke-Ollendorff syndrome: They found elevated levels of IL-15, IL-17, tumor necrosis factor-α (TNF-α) and myeloperoxidase, highlighting the role of neutrophilic inflammation, and lower levels of alpha 1 antitrypsin in BALF collected between 6 and 12 months after transplantation from patients who developed BOS by 30 months post-transplant.