The iDCs exert weaker activating effects on T cells by expressing lower amounts of costimulatory cytokines, including IL-6 and IL-12 in patients with SLE; this observation is consistent with iDCs' effects in lupus-like mice where iDCs lower the responses of Th1/Th2 cells and thus inhibit the secretion of IL-2, IL-4, IL-12, and interferon γ and the formation of anti-dsDNA IgG (130–132). This evidence concerns the gene IL6 and systemic lupus erythematosus.