The mRNA expression levels of TWEAK and Fn14 increase in the glomeruli and tubulointerstitium in both LN patients and in a mouse model and act as an inducer of constitutive nuclear factor (NF-κB) activation, which mediates the expression of MCP-1, interferon γ-induced protein 10 (IP-10), macrophage inflammatory protein 1a, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 (83, 84). The gene discussed is TNFSF12; the disease is lobular neoplasia.