The adoptive transfer of B10 cells, previously cultured with P. gingivalis LPS and cytosine-phospho-guanine (CpG) oligodeoxynucleotides, into mice with P. gingivalis and ligature-induced periodontitis, showed a significant reduction of bone loss and gingival inflammation, associated with increased local IL-10 production (70). The gene discussed is IL10; the disease is periodontitis.