Two key ICD-related DAMPs have been identified as nuclear non-histone chromatin protein high mobility group box 1 (HMGB1) (47) and surface heat shock protein 90 (HSP90) (48), which are capable of signaling as endogenous ligands of Toll-like receptor-4 (TLR-4) on DCs, leading to their processing and presentation of tumor-associated antigens, rendering the cell death immunogenic rather than tolerogenic. Here, TLR4 is linked to neoplasm.