Splenic macrophages (F4/80+ CD11blow) which had become activated by PIFAs via leukotriene B4 receptor 2 (BLT2) secreted polyunsaturated lysophosphatidylcholines (LPCs) which were capable of altering the DNA damage response in the distant tumor, and conferred therapy resistance (99). This evidence concerns the gene LTB4R2 and neoplasm.