In contrast to anti-CD20 treated patients, no case in the control group of patients under intense oral immunosuppression had severe hypogammaglobulinemia or severe IgA deficiency, whereas 11/17 and 3/17 patients had low IgG (<700 mg/dl) or IgA (<70 mg/dl) levels, respectively, and 1/17 patients had low IgM (<40 mg/dl) (Figure 1; Table 1). The gene discussed is CD40LG; the disease is Decreased circulating immunoglobulin concentration.