As mitogen-activated protein (MAP) kinases have been implicated in many CD8+ T cell physiological processes, including cell proliferation, differentiation, and death (38) and p38 MAP kinase regulates IFNγ production in CD8+ T cells (39), the investigation of T cell MAP kinase signalosome is necessary to further clarify the ERAP2-HIV-infection axis. Here, IFNG is linked to infection.