Since IFN type I and IFN type II can induce the expression of PD-L1 in cancer cells, we also use siRNAs targeting IFNAR2 or IFNGR1 to silence expression of IFNAR2 or INFGR1 in HCC cells (Supplementary Figures 3A,B). The gene discussed is IFNGR1; the disease is hepatocellular carcinoma.